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- Original Article
- Comparison of air pollution and the prevalence of allergy-related diseases in Incheon and Jeju City
- Su Ho Jeong, Jeong Hee Kim, Byong Kwan Son, Seong Chul Hong, Su Young Kim, Geun Hwa Lee, Dae Hyun Lim
- Clin Exp Pediatr. 2011;54(12):501-506. Published online December 31, 2011
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Purpose A high level of air pollutants can increase the number of patients with allergy-related diseases such as asthma and allergic rhinitis (AR). To analyze the association between air pollution and allergic disease, we investigated 2 areas in Korea: Incheon, an industrial area, and Jeju, a non-industrialized area.
Methods Second grade students at elementary schools (11 schools in Incheon and 45 schools in...
- Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma
- Yanghua Ju, Seung Jun Choi, Huisu Lee, Hyun Sook Kim, Sulmui Won, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Joon Sung Lee
- Clin Exp Pediatr. 2011;54(11):456-462. Published online November 30, 2011
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Purpose Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question.
Methods We prepared
Dermatophagoides...
- Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma
- Byoung-Ju Kim, Ji-Won Kwon, Ju-Hee Seo, Won-Ah Choi, Young-Jun Kim, Mi-Jin Kang, Jinho Yu, Soo-Jong Hong
- Clin Exp Pediatr. 2011;54(9):373-379. Published online September 30, 2011
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Purpose 4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model.
Methods BALB/c mice were sensitized to and challenged with ovalbumin (OVA). Hu.4-1BB-Fc was administered 1 day before the first OVA...
- Review Article
- Asthma in childhood: a complex, heterogeneous disease
- Hai Lee Chung
- Clin Exp Pediatr. 2011;54(1):1-5. Published online January 31, 2011
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Asthma in childhood is a heterogeneous disease with different phenotypes and variable clinical manifestations, which depend on the age, gender, genetic background, and environmental influences of the patients. Several longitudinal studies have been conducted to classify the phenotypes of childhood asthma, on the basis of the symptoms, triggers of wheezing illness, or pathophysiological features of the disease. These studies have...
- Original Article
- The role of inhaled and/or nasal corticosteroids on the bronchodilator response
- Ju Kyung Lee, Dong In Suh, Young Yull Koh
- Clin Exp Pediatr. 2010;53(11):951-956. Published online November 30, 2010
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Purpose To compare the profiles of the bronchodilator response (BDR) among children with asthma and/or allergic rhinitis (AR) and to determine whether BDR in these children is reduced by treatment with inhaled and/or nasal corticosteroid.
Methods Sixty-eight children with asthma (mean age, 10.9 years), 45 children with comorbid asthma and AR (mean age, 10.5 years), and 44 children with AR alone (mean age,...
- Increased B cell-activating factor (BAFF) level in the sputum of children with asthma
- Hye Mi Jee, Bong Seok Choi, Kyung Won Kim, Myung Hyun Sohn, Man Yong Han, Kyu-Earn Kim
- Clin Exp Pediatr. 2010;53(8):795-800. Published online August 31, 2010
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Purpose B cell-activating factor (BAFF) is a tumor-necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is observed in naïve cells as well as in effector/memory T cells. We aimed to explore whether BAFF in sputum is expressed at elevated levels in asthmatic airways and associated with eosinophilic inflammation, pulmonary...
- The effects of early allergen/endotoxin exposure on subsequent allergic airway inflammation to allergen in mouse model of asthma
- Yeong-Ho Rha, Sun-Hee Choi
- Clin Exp Pediatr. 2010;53(4):481-487. Published online April 15, 2010
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Purpose : Recently many studies show early exposure during childhood growth to endotoxin (lipopolysaccharides, LPS) and/or early exposure to allergens exhibit important role in development of allergy including bronchial asthma. The aim of this study was to evaluate the role of endotoxin and allergen exposure in early life via the airways in the pathogenesis of allergic airways inflammation and airway hyperresposiveness... -
- Clinical characteristics of acute lower respiratory tract infections due to 13 respiratory viruses detected by multiplex PCR in children
- Jeong-Sook Lim, Sung-Il Woo, Hyuk-Il Kwon, Hyuk-Il Kwon, Young-Ki Choi, Youn-Soo Hahn
- Clin Exp Pediatr. 2010;53(3):373-379. Published online March 15, 2010
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Purpose : This study was performed to investigate the epidemiologic and clinical features of 13 respiratory viruses in children with acute lower respiratory tract infections (ALRIs). Methods : Nasopharyngeal aspirates were prospectively obtained from 325 children aged 15 years or less from May 2008 to April 2009 and were tested for the presence of 13 respiratory viruses by multiplex real-time-polymerase chain... -
- Caregivers’adherence factors affecting maintenance treatment in children with well-controlled asthma : A qualitative analysis through in-depth interview
- Ic Sun Choi, Saeng Koo Cho, Kyong Suk La, Jung Hye Byeon, Dae Jin Song, Young Yoo, Ji Tae Choung
- Clin Exp Pediatr. 2010;53(3):364-372. Published online March 15, 2010
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Purpose : Good adherence of caregivers is essential for successful health outcomes in the treatment of childhood asthma. The purpose of this study was to identify the factors contributing to good adherence of maintenance treatment in children with well-controlled asthma. Methods : Children with well-controlled asthma being treated with a daily controller for at least 3 months in Korea University... -
- Review Article
- Natural killer T cell and pathophysiology of asthma
- Gwang Cheon Jang
- Clin Exp Pediatr. 2010;53(2):136-145. Published online February 15, 2010
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Natural killer T (NKT) cell is a special type of T lymphocytes that has both receptor of natural killer (NK) cell (NK1.1, CD161c) and T cell (TCR) and express a conserved or invariant T cell receptor called Vα14Jα18 in mice or Va24 in humans. Invariant NKT (iNKT) cell recognizes lipid antigen presented by CD1d molecules. Marine-sponge-derived glycolipid, α- galactosylceremide (α-GalCer),... -
- Human rhinoviruses and asthma in children
- Woo Kyung Kim
- Clin Exp Pediatr. 2010;53(2):129-135. Published online February 15, 2010
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Human rhinoviruses (HRVs) is a nonenveloped, single stranded RNA virus belonging to the family Picornavirudae. Transmission by direct contact such as hand-to-hand, hand-to-nose, and hand-to-eye has been readily demonstrated in experimental settings. HRV are the most frequent causes of common cold infection, however, they are also known to replicate in the lower respiratory tract and associated with more severe respiratory... -
- Environmental tobacco smoke and childhood asthma
- Dae Jin Song
- Clin Exp Pediatr. 2010;53(2):121-128. Published online February 15, 2010
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In recent years, environmental tobacco smoke (ETS) has become an important worldwide public health issue. Children are particularly vulnerable to ETS because they are still developing. ETS exposure causes a wide range of adverse health effects on childhood asthma. There is convincing evidence that ETS exposure is causally associated with an increased prevalence of asthma, increased severity of asthma and... -
- Original Article
- Effects of inhaled corticosteroids on bone mineral density and bone metabolism in children with asthma
- Ic Sun Choi, Jung Hye Byeon, Seung Min Lee, Kyong Suk La, Yeon Joung Oh, Young Yoo, Kee Hyoung Lee, Ji Tae Choung
- Clin Exp Pediatr. 2009;52(7):811-817. Published online July 15, 2009
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Purpose : Inhaled corticosteroids (ICS) are used as first-line agents for the treatment of persistent asthma; however, their use is accompanied by apprehension of potential systemic adverse effects. This study aimed to assess the effects of ICS on bone mineral density (BMD) and bone metabolism in children with asthma. Methods : From February 2008 to September 2008, 26 asthmatic children treated... -
- Association study of polymorphism in leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes with phenotype of asthma and clinical parameters in Korean children
- Jung Yeon Shim, Byung-Joo Kim, Young Hwa Song, Mi-Jin Kang, So-Yeon Lee, Jinho Yu, Soo-Jong Hong
- Clin Exp Pediatr. 2009;52(6):680-688. Published online June 15, 2009
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Purpose : Cysteinyl leukotrienes are important proinflammatory mediators in asthma. Recently, it was suggested that a promoter polymorphism in the genes encoding for leukotriene C4 synthase (LTC4S), a key enzyme in the leukotriene synthetic pathway, and cysteinyl leukotriene receptor 1 (CysLTR1) might be associated with aspirin-intolerant asthma. We investigated whether polymorphisms in LTC4S and CysLTR1 genes or their interactions were... -
- Comparison between adverse effects of low and usual doses of intravenous aminophylline
- Bok Ki Kim, Dae Hyun Lim, So Hyun Ahn, Jong Hoon Kwa, Jeong Hee Kim, Byong Kwan Son
- Clin Exp Pediatr. 2009;52(4):441-445. Published online April 15, 2009
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Purpose : Some patients develop side effects from theophylline even at low serum concentrations. We designed a prospective study to evaluate the side effects of theophylline. Methods : A Prospective, controlled trial study was conducted. The low-dose group received an intravenous continuous aminophylline dose of 5 mg/kg/day on the first day and subsequently 10 mg/kg/day on the following two days.... -
- Relationship between cord blood level of IL-12 in preterm newborns and development of wheezing
- Hyo Jung Yu, Eun Ae Park, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye Sook Park, Eun Hee Ha
- Clin Exp Pediatr. 2008;51(7):754-759. Published online July 15, 2008
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Purpose : Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy Methods... -
- Review Article
- The prevalences of asthma and allergic diseases in Korean children
- Soo-Jong Hong, Kang-Mo Ahn, Soo-Young Lee, Kyu-Earn Kim
- Clin Exp Pediatr. 2008;51(4):343-350. Published online April 15, 2008
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Asthma and allergic diseases are one of the most common disorders in children. Due to its increased prevalence, as well as the increased morbidity and mortality from these diseases, asthma and allergic diseases have come to be recognized as a major worldwide public health issue. In addition, socioeconomic burden of asthma and allergic diseases has increased in Korea also. The... -
- Original Article
- Utility of a forced expiratory flow of 25 to 75 percent as a predictor in children with asthma
- Jung Wan Kang, Kyung Won Kim, Eun Soo Kim, Jun Young Park, Myung Hyun Sohn, Kyu-Earn Kim
- Clin Exp Pediatr. 2008;51(3):323-328. Published online March 15, 2008
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Purpose : Asthma is defined as chronic inflammation of the lower small airways, and bronchial hyperreactivity (BHR) is a pathophysiologic feature of asthma. It has been proposed that although there is no direct variable capable of assessing the small airways, a forced expiratory flow of between 25 and 75 percent (FEF25-75) might be considered a more sensitive early marker of... -
- Effects of an intensive asthma education program on asthmatic children and their caregivers
- Kang Jin Seo, Gun Ha Kim, Byung Keun Yu, Yun Ku Yeo, Jong Hoon Kim, Eu Ddeum Shim, Mi Ri Yoon, Young Yoo, Ji Tae Choung
- Clin Exp Pediatr. 2008;51(2):188-203. Published online February 15, 2008
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Purpose : Asthma is one of the most common chronic childhood disease. Education of asthmatic children and their families about asthma and its management may improve disease control, reduce symptoms, and improve school performance. The aim of the study was to evaluate the effects of an intensive asthma education program in asthmatic children and their families on outcome measure... -
- Relationship between exhaled nitric oxide and pulmonary function test in children with asthma
- Han-Seok Ko, Sung-Hoon Chung, Yong-Sung Choi, Sun-Hee Choi, Yeong-Ho Rha
- Clin Exp Pediatr. 2008;51(2):181-187. Published online February 15, 2008
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Purpose : Asthma is characterized by reversible airway obstruction and bronchial hyperresponsiveness result from airway inflammation. Fraction of nitric oxide in expired air (FeNO) has recently been investigated as a noninvasive measure of airway inflammation. FeNO has been reported to correlate with induced sputum eosinophilia and methacholine challenge test that it is represent severity of asthma. The purpose of this... -
- Analysis of the association between bronchial hyperresponsiveness and genetic polymorphism of β2-adrenoceptor in adolescents with long-term asthma remission
- Hee Kang, Young Yull Koh
- Clin Exp Pediatr. 2007;50(6):556-564. Published online June 15, 2007
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Purpose : We hypothesized that the persisting bronchial hyperresponsiveness (BHR) of adolescents with asthma remission may be controlled mainly by genetic factors, and the BHR of symptomatic asthma by airway inflammation. β2-adrenoceptor gene is considered to be a candidate gene in the development of BHR. Thus, β2-adrenoceptor gene polymorphism may be associated with the BHR of adolescents with asthma remission,... -
- Review Article
- Allergic rhinitis, sinusitis and asthma - evidence for respiratory system integration -
- Hyun Hee Kim
- Clin Exp Pediatr. 2007;50(4):335-339. Published online April 15, 2007
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The link between upper airway disease (allergic rhinitis and sinusitis) and lower airway disease (asthma) has long been of interest to physicians. Many epidemiological and pharmacological studies have provided a better understanding of pathophysiologic interrelationship between allergic rhinitis and asthma. The vast majority of patients with asthma have allergic rhinitis, and rhinitis is a major independent risk factor for asthma... -
- Original Article
- Therapeutic comparison between low-dose sustained-release theophylline dry syrup and capsule in children with mild persistent asthma
- Hyun Seung Lee, Hae Kyung Lee, Hi Jeong Kwon, Jeong Hee Kim, Yeong Ho Rha, Jin Tack Kim, Young Ho Kim, Hae Rhan Lee, Bok Yang Pyun
- Clin Exp Pediatr. 2007;50(3):284-291. Published online March 15, 2007
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Purpose : Theophylline has recently been reported to have concurrent anti-inflammatory effects at low therapeutic plasma concentrations which are below the doses at which significants, clinically useful bronchodilatation is evident. Sustained-release formulation in capsule and dry syrup forms were developed to reduce its adverse effects and improve its clinical effects. We compared the therapeutic effects of theophylline dry syrup and... -
- Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
- Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
- Clin Exp Pediatr. 2006;49(8):889-894. Published online August 15, 2006
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Purpose : Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the... -
- Review Article
- Update in asthma management
- Hae Ran Lee
- Clin Exp Pediatr. 2006;49(6):581-588. Published online June 15, 2006
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Asthma is a chronic inflammation of the airway associated with increased bronchial hyperresponsiveness that leads to recurrent episodes of cough, wheezing, breathless, chest tightness. According the recent studies, repeated airway inflammation leads to structural changes so called ‘airway remodeling’ and associated with decreased pulmonary function. Airway remodeling begins form the early stage of asthma and the early diagnosis and management... -
- Original Article
- The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia
- Seong Hwan Choi, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
- Clin Exp Pediatr. 2006;49(2):192-197. Published online February 15, 2006
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Purpose : Vascular endothelial growth factor(VEGF) is a key cytokine for controlling vascular permeability and angiogenesis, which is one of the major findings in airway remodeling. However, it is not well known if it is associated with acute lower respiratory tract disease such as lobar pneumonia. The aim of this study is to compare serum VEGF levels in patients with... -
- Relationship between △FVC(% fall in FVC at the PC20 Dose of Methacholine) and Serum Eosinophil Cationic Protein(ECP) in 6-8 Year Old Children with Asthma
- Dong In Suh, Jinho Yu, Young Yoo, Do Kyun Kim, Hee Kang, Young Yull Koh
- Clin Exp Pediatr. 2005;48(10):1126-1131. Published online October 15, 2005
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Purpose : Bronchial hyperresponsiveness(BHR) is considered a hallmark of asthma. Increased levels of eosinophil cationic protein(ECP) have been identified in serum of asthma patients. Several studies have examined the relationship between serum ECP and bronchial responsiveness, expressed as methacholine PC20 in asthmatic patients, with conflicting results. The aims of this study were to examine the relationship between serum ECP and... -
- Clinical Lecture
- Airway Remodelling in Asthma
- Dae Hyun Lim
- Clin Exp Pediatr. 2005;48(10):1038-1049. Published online October 15, 2005
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Asthma is characterized by a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodelling. Characteristic changes of airway remodelling in asthma include goblet cell hyperplasia, deposition of collagens in the basement membrane, increased number and size of microvessels, hypertrophy and hyperplasia of airway smooth muscle, and hypertrophy of submucosal glands.... -
- Original Article
- Effects of Hyperosmolar Stimuli on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
- Byoung Chul Kwon, Eun Soo Kim, Kyung Won Kim, Tae Won Song, Myung Hyun Sohn, Myeong Heon Shin, Kyu-Earn Kim
- Clin Exp Pediatr. 2005;48(8):881-885. Published online August 15, 2005
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Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide... -
- Association of Leukotriene C4 Synthase Gene Polymorphism with Clinical Response to Montelukast in Childhood Asthma
- Kyung-Sue Shin, Youn Woo Kim
- Clin Exp Pediatr. 2005;48(7):766-771. Published online July 15, 2005
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목 적 : 류코트리엔 수용체 길항제는 천식의 병리 반응에 관여하는 cysteiny leukotriene의 생성과 작용을 억제하여 급성기 천식 증상의 치료와 천식 증상의 조절 요법에 사용할 수 있다. 본 연구에서는 소아 천식환자에서 cysteinyl leukotriene 생성에 관여하는 LTC4S 유전자 다형태와 류코트리엔 수용체 길항제인 montelukast의 임상적 효과를 조사하여 약물유전학적 연관성 유무를 알고자 하였다. 방 법 : 환자군은 경증 지속성 천식과 중등증 지속성 천식환자 161명을 대상으로... -
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
